解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS:We inhibited I...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001198
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Presentation of pancreatic adenocarcinoma (PC) as acute pancreatitis (AP), association of chronic pancreatitis (CP) with PC, and role of inflammation in PC carcinogenesis are well recognized. We hypothesized that inflammatory changes associated with remote history of AP (≥2 years before PC diagnosis) would r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001160
更新日期:2018-11-01 00:00:00
abstract::High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the cl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001171
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001142
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METH...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001150
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS:One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis usi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001147
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001123
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001100
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000001071
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001064
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001038
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001019
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000001016
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS:A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000000990
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraducta...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001002
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000977
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000987
更新日期:2018-02-01 00:00:00
abstract::The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without possibility of cure. Although in recent years there have been some new promising chemotherapy regimens that improve overall survival by a few months, the prognosis re...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000000948
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Recent observations demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in sensory ganglion neurons. Because sensory nerves are implicated in pancreatic inflammatory processes, we studied the colocal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000959
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the perioperative clinical characteristics between patients with distal cholangiocarcinoma (DCC) and pancreatic head carcinoma (PHC) with biliary obstruction. METHODS:This study included patients who underwent pancreatoduodenectomy and were diagnosed with DCC (n = 85) or...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000942
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000911
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS:Thirty-nine pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000917
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:This study aims to identify the computed tomography (CT) features that may differentiate nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) with lymph node (LN) metastasis from NF-PanNETs without lymph node metastasis. METHODS:We retrospectively analyzed 166 NF-PanNETs in 166 patients who had unde...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000888
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000861
更新日期:2017-08-01 00:00:00
abstract::The recent publication of evidence-based guidelines by the American Gastroenterological Association for the management of the incidental pancreatic cyst has stimulated considerable discussion among clinicians and researchers. The guidelines examined the evidence in an accompanying technical review defining current dia...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000000832
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000835
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000786
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000765
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000772
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by othe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000758
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000717
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000726
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000685
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000634
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Our aim was to establish and characterize a novel pancreatic ductal adenocarcinoma cell line from a patient in whom the origin of the invasive carcinoma could be traced back to the intraductal papillary mucinous neoplasm (IPMN) precursor lesion. METHODS:The primary patient-derived tumor was propagated in im...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000673
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000693
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000633
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000605
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000574
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000637
更新日期:2016-08-01 00:00:00